姚红杰研究员
研究简介
本团队聚焦干细胞命运调控及肺癌发生机制与转化研究。前期在多能（或全能）干细胞诱导、维持与分化的表观遗传调控领域取得一系列重要成果，揭示了多维表观信息在干细胞命运调控中的关联调控机制及其生物学功能。当前课题组重点围绕三方面开展研究：1）开发表观遗传新技术，解析多维度表观信息在不同生命活动中的动态关联调控机制；2）阐明肺结节起源及癌变的分子机制，筛选良恶性肺结节转变的关键靶标，并研发干预策略；3）探究小细胞肺癌表型转变的机理，鉴定调控其恶性进展的分子开关，开发延长患者生存期的策略。
荣誉奖励
1. 广东省科学技术奖自然科学奖一等奖（2022）（第一完成人）
2. 国家重点研发计划项目首席科学家（2021）
3. 广州市黄埔区杰出人才（2021）
4. 国家杰出青年科学基金获得者（2019）
5. 广州市杰出人才（2019）
代表性成果
1. Yaoyi Li#, Yingliang Sheng#, Chao Di, Hongjie Yao*. Base-pair resolution reveals clustered R-loops and DNA damage-susceptible R-loops. Molecular Cell 2025 Apr 17; 85(8):1686-1702.e5. (Featured Article)
2. Xiuqin Wang, Gongcheng Hu, Lisha Wang, Yuli Lu, Yanjiang Liu, Shengxiong Yang, Junzhi Liao, Qian Zhao, Qiuling Huang, Wentao Wang, Wenjing Guo, Heying Li, Yu Fu, Yawei Song, Qingqing Cai, Xiaofei Zhang, Xiangting Wang, Yue-Qin Chen, Xiaorong Zhang, Hongjie Yao*. DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells. Nature Communications 2024 Nov 27; 15(1):10303. (Highlighted by Nature Communications Editor).
3. Rong Guo#, Xiaotao Dong#, Feng Chen, Tianrong Ji, Qiannan He, Jie Zhang, Yingliang Sheng, Yanjiang Liu, Shengxiong Yang, Weifang Liang, Yawei Song, Ke Fang, Lingling Zhang, Gongcheng Hu, Hongjie Yao*. TEAD2 initiates the ground-state pluripotency by mediating chromatin looping. The EMBO Journal 2024 May; 43(10):1965-1989.
4. Jie Zhang#, Gongcheng Hu#, Yuli Lu#, Huawei Ren#, Yin Huang, Yulin Wen, Binrui Ji, Diyang Wang, Haidong Wang, Huisheng Liu, Ning Ma, Lingling Zhang, Guangjin Pan, Yibo Qu, Hua Wang, Wei Zhang, Zhichao Miao, Hongjie Yao*. CTCF mutation at R567 causes developmental disorders by 3D genome rearrangement and abnormal neurodevelopment. Nature Communications 2024 Jul 1; 15(1):5524.
5. Yanjiang Liu#, Gongcheng Hu#, Shengxiong Yang, Mingze Yao, Zicong Liu, Chenghong Yan, Yulin Wen, Wangfang Ping, Juehan Wang, Yawei Song, Xiaotao Dong, Guangjin Pan, Hongjie Yao*. Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells. Nature Communications 2023 Nov 7; 14(1):7164.
6. Wangfang Ping#, Yingliang Sheng#, Gongcheng Hu, Hongxin Zhong, Yaoyi Li, YanJiang Liu, Wei Luo, Chenghong Yan, Yulin Wen, Xinxiu Wang, Qing Li, Rong Guo, Jie Zhang, Ake Liu, Guangjin Pan, Hongjie Yao*. RBBP4 is an epigenetic barrier to the induced transition of pluripotent stem cells into totipotent 2C-like cells. Nucleic Acids Research 2023 Jun 23; 51(11):5414-5431.
7. Xiaotao Dong#, Rong Guo#, Tianrong Ji, Jie Zhang, Jun Xu, Yaoyi Li, Yingliang Sheng, Yuxiang Wang, Ke Fang, Yulin Wen, Bei Liu, Gongcheng Hu, Hongkui Deng, Hongjie Yao*. 2022. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency. Nucleic Acids Research 2022 Nov 28; 50(21):12019-12038.
8. Yawei Song#, Zhengyu Liang#, Jie Zhang#, Gongcheng Hu#, Juehan Wang, Yaoyi Li, Rong Guo, Xiaotao Dong, Isaac A. Babarinde, Wangfang Ping, Ying-Liang Sheng, Huanhuan Li, Zhaoming Chen, Minghui Gao, Yang Chen, Ge Shan, Michael Q. Zhang, Andrew P. Hutchins, Xiang-Dong Fu, Hongjie Yao*. CTCF functions as an insulator for somatic genes and a chromatin Remodeler for Pluripotency Genes during Reprogramming. Cell Reports 2022 Apr 5; 39(1):110626.
9. Gongcheng Hu#, Xiaotao Dong#, Shixin Gong#, Yawei Song, Andrew P. Hutchins, Hongjie Yao*. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research. 2020 Sep 25; 48(17):9606-9620.
10. 一种全基因组R-loop检测方法及应用，PCT专利，申请号：PCT/CN2025/071300，申请日期：2025年01月08日，排序：姚红杰、李尧益、盛英梁。
2. Xiuqin Wang, Gongcheng Hu, Lisha Wang, Yuli Lu, Yanjiang Liu, Shengxiong Yang, Junzhi Liao, Qian Zhao, Qiuling Huang, Wentao Wang, Wenjing Guo, Heying Li, Yu Fu, Yawei Song, Qingqing Cai, Xiaofei Zhang, Xiangting Wang, Yue-Qin Chen, Xiaorong Zhang, Hongjie Yao*. DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells. Nature Communications 2024 Nov 27; 15(1):10303. (Highlighted by Nature Communications Editor).
3. Rong Guo#, Xiaotao Dong#, Feng Chen, Tianrong Ji, Qiannan He, Jie Zhang, Yingliang Sheng, Yanjiang Liu, Shengxiong Yang, Weifang Liang, Yawei Song, Ke Fang, Lingling Zhang, Gongcheng Hu, Hongjie Yao*. TEAD2 initiates the ground-state pluripotency by mediating chromatin looping. The EMBO Journal 2024 May; 43(10):1965-1989.
4. Jie Zhang#, Gongcheng Hu#, Yuli Lu#, Huawei Ren#, Yin Huang, Yulin Wen, Binrui Ji, Diyang Wang, Haidong Wang, Huisheng Liu, Ning Ma, Lingling Zhang, Guangjin Pan, Yibo Qu, Hua Wang, Wei Zhang, Zhichao Miao, Hongjie Yao*. CTCF mutation at R567 causes developmental disorders by 3D genome rearrangement and abnormal neurodevelopment. Nature Communications 2024 Jul 1; 15(1):5524.
5. Yanjiang Liu#, Gongcheng Hu#, Shengxiong Yang, Mingze Yao, Zicong Liu, Chenghong Yan, Yulin Wen, Wangfang Ping, Juehan Wang, Yawei Song, Xiaotao Dong, Guangjin Pan, Hongjie Yao*. Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells. Nature Communications 2023 Nov 7; 14(1):7164.
6. Wangfang Ping#, Yingliang Sheng#, Gongcheng Hu, Hongxin Zhong, Yaoyi Li, YanJiang Liu, Wei Luo, Chenghong Yan, Yulin Wen, Xinxiu Wang, Qing Li, Rong Guo, Jie Zhang, Ake Liu, Guangjin Pan, Hongjie Yao*. RBBP4 is an epigenetic barrier to the induced transition of pluripotent stem cells into totipotent 2C-like cells. Nucleic Acids Research 2023 Jun 23; 51(11):5414-5431.
7. Xiaotao Dong#, Rong Guo#, Tianrong Ji, Jie Zhang, Jun Xu, Yaoyi Li, Yingliang Sheng, Yuxiang Wang, Ke Fang, Yulin Wen, Bei Liu, Gongcheng Hu, Hongkui Deng, Hongjie Yao*. 2022. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency. Nucleic Acids Research 2022 Nov 28; 50(21):12019-12038.
8. Yawei Song#, Zhengyu Liang#, Jie Zhang#, Gongcheng Hu#, Juehan Wang, Yaoyi Li, Rong Guo, Xiaotao Dong, Isaac A. Babarinde, Wangfang Ping, Ying-Liang Sheng, Huanhuan Li, Zhaoming Chen, Minghui Gao, Yang Chen, Ge Shan, Michael Q. Zhang, Andrew P. Hutchins, Xiang-Dong Fu, Hongjie Yao*. CTCF functions as an insulator for somatic genes and a chromatin Remodeler for Pluripotency Genes during Reprogramming. Cell Reports 2022 Apr 5; 39(1):110626.
9. Gongcheng Hu#, Xiaotao Dong#, Shixin Gong#, Yawei Song, Andrew P. Hutchins, Hongjie Yao*. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research. 2020 Sep 25; 48(17):9606-9620.
10. 一种全基因组R-loop检测方法及应用，PCT专利，申请号：PCT/CN2025/071300，申请日期：2025年01月08日，排序：姚红杰、李尧益、盛英梁。