金方研究员
研究简介
主要从事药物新剂型及其重大品种产业化的研究，积极参与国家药用吸入气雾剂氟利昂替代的相关政策制订，是2000版、2010版､2015版、2020版中国药典吸入制剂相关通则与测定法的主要起草人，全程参与我国经口吸入制剂从无到有的发展历程和标准建立过程。先后负责国家863、国家重点攻关的多个项目；主译国外专著《固体口服制剂的研发:药学理论与实践》、《呼吸道药物递送的基本理论与实践》；发表70余篇SCI/核心论文；获40余项中国专利授权／欧洲专利授权；近五年负责研发的吸入制剂有10个产品、14个品规获批上市，完成国内首个吸入溶液剂、吸入粉雾剂的一致性评价；获批国内首个吸入抗生素；负责生物创新药新冠重组蛋白疫苗V-01、重组新型冠状病毒融合蛋白二价苗的临床研究，均被国家纳入紧急使用。
荣誉奖励
1. 中国药学会制药工程专业委员会主任委员
2. 第九、十、十一、十二届国家药典委员会委员
3. 国务院政府特殊津贴
4. 人事部“新世纪百千万人才工程”国家级人选
5. 上海市“三八红旗手”
6. 全国优秀科技工作者
代表性成果
1. Yan Chen, Lei Zhou, Ling Yuan, Zhenhai Zhang, Xuan Liu, Qingqing Wu, Fang Jin（*）,10.2147/IJN.S32476, Formulation, Optimization, Characterization, and Pharmacokinetics of Progesterone Intravenous Lipid Emulsion for Traumatic Brain Injury Therapy. Pharmaceutical Science, 43/171.
2. Xiaoxia Ye, Juan Ma, Yongjian Yang, Fang Jin（*), 10.1039/c3ay42047g, Analysis of 21 phthalate leachables in metered dose inhalers by gas chromatography tandem mass spectrometry. SCI, Chemistry, 44/110.
3. Jiahua Deng, Weihui Cai, Fang Jin（*）, 10.1016/j.ijpharm. 2014.04.003 A novel oil-in-water emulsion as a potential adjuvant for influenza vaccine. Development, characterization, stability and in vivo evaluation. SCI, Pharmaceutical Science, 68/219
4. LL Shen, YN Liu, HJ Shen, C Wen, YL Jia, XW Dong, F Jin（*）, XP Chen, Y Sun, QM Xie ,10.1016/j.intimp. 2013.12.021, Inhalation of glycopyrronium inhibits cigarette smoke-induced acute lung inflammation in a murine model of COPD SCI, Pharmacology, 50/301.
5. Feihu Wang a b, Yun Wang a, Xiao Zhang a, Wenjun Zhang a, Shengrong Guo a, Fang Jin b（*), 10.1016/j.jconrel.2013.11.020, Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery SCI, Pharmacology, toxicology and Pharmaceutics, 3/183.
6. Jieqiong You, Ying Wang, Haifeng Chen, Fang Jin（*), 10.3389/fphar.2023.1192970, RIPK2: a promising target for cancer treatment, SCI, 生物化学与分子生物学 81/297.
7. Xuan-Yi Wang, Syed Faisal Mahmoodd, Fang Jine (#), Wee Kooi Cheahg, Muhammad Ahmadh, Mian Amjad Sohaili, Waheed Ahmadj, Vijaya K. Suppank, Muneeba Ahsan Sayeedl, Shobha Luxmim, Aik-Howe Teon, Li Yuan Leeo, Yang-Yang Qi, Rong-Juan Pei, Wei Deng, Zhong-Hui Xu, Jia-Ming Yang, Yan Zhang, Wu-Xiang Guan and Xiong Yu, 10.1080/22221751.2022.2088406 , Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial. SCI, Infection Diseases 8/96.
8. 一种吸入用布地奈德混悬液的制备方法，中国，ZL202111002317.5
9. 一种氟替卡松原料药粒径的测试方法，中国，ZL202010240869.9
10. 真空履带式烘箱生产依维莫司固体分散体的方法，中国，ZL202210231728.X
主要从事药物新剂型及其重大品种产业化的研究，积极参与国家药用吸入气雾剂氟利昂替代的相关政策制订，是2000版、2010版､2015版、2020版中国药典吸入制剂相关通则与测定法的主要起草人，全程参与我国经口吸入制剂从无到有的发展历程和标准建立过程。先后负责国家863、国家重点攻关的多个项目；主译国外专著《固体口服制剂的研发:药学理论与实践》、《呼吸道药物递送的基本理论与实践》；发表70余篇SCI/核心论文；获40余项中国专利授权／欧洲专利授权；近五年负责研发的吸入制剂有10个产品、14个品规获批上市，完成国内首个吸入溶液剂、吸入粉雾剂的一致性评价；获批国内首个吸入抗生素；负责生物创新药新冠重组蛋白疫苗V-01、重组新型冠状病毒融合蛋白二价苗的临床研究，均被国家纳入紧急使用。
荣誉奖励
1. 中国药学会制药工程专业委员会主任委员
2. 第九、十、十一、十二届国家药典委员会委员
3. 国务院政府特殊津贴
4. 人事部“新世纪百千万人才工程”国家级人选
5. 上海市“三八红旗手”
6. 全国优秀科技工作者
代表性成果
1. Yan Chen, Lei Zhou, Ling Yuan, Zhenhai Zhang, Xuan Liu, Qingqing Wu, Fang Jin（*）,10.2147/IJN.S32476, Formulation, Optimization, Characterization, and Pharmacokinetics of Progesterone Intravenous Lipid Emulsion for Traumatic Brain Injury Therapy. Pharmaceutical Science, 43/171.
2. Xiaoxia Ye, Juan Ma, Yongjian Yang, Fang Jin（*), 10.1039/c3ay42047g, Analysis of 21 phthalate leachables in metered dose inhalers by gas chromatography tandem mass spectrometry. SCI, Chemistry, 44/110.
3. Jiahua Deng, Weihui Cai, Fang Jin（*）, 10.1016/j.ijpharm. 2014.04.003 A novel oil-in-water emulsion as a potential adjuvant for influenza vaccine. Development, characterization, stability and in vivo evaluation. SCI, Pharmaceutical Science, 68/219
4. LL Shen, YN Liu, HJ Shen, C Wen, YL Jia, XW Dong, F Jin（*）, XP Chen, Y Sun, QM Xie ,10.1016/j.intimp. 2013.12.021, Inhalation of glycopyrronium inhibits cigarette smoke-induced acute lung inflammation in a murine model of COPD SCI, Pharmacology, 50/301.
5. Feihu Wang a b, Yun Wang a, Xiao Zhang a, Wenjun Zhang a, Shengrong Guo a, Fang Jin b（*), 10.1016/j.jconrel.2013.11.020, Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery SCI, Pharmacology, toxicology and Pharmaceutics, 3/183.
6. Jieqiong You, Ying Wang, Haifeng Chen, Fang Jin（*), 10.3389/fphar.2023.1192970, RIPK2: a promising target for cancer treatment, SCI, 生物化学与分子生物学 81/297.
7. Xuan-Yi Wang, Syed Faisal Mahmoodd, Fang Jine (#), Wee Kooi Cheahg, Muhammad Ahmadh, Mian Amjad Sohaili, Waheed Ahmadj, Vijaya K. Suppank, Muneeba Ahsan Sayeedl, Shobha Luxmim, Aik-Howe Teon, Li Yuan Leeo, Yang-Yang Qi, Rong-Juan Pei, Wei Deng, Zhong-Hui Xu, Jia-Ming Yang, Yan Zhang, Wu-Xiang Guan and Xiong Yu, 10.1080/22221751.2022.2088406 , Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial. SCI, Infection Diseases 8/96.
8. 一种吸入用布地奈德混悬液的制备方法，中国，ZL202111002317.5
9. 一种氟替卡松原料药粒径的测试方法，中国，ZL202010240869.9
10. 真空履带式烘箱生产依维莫司固体分散体的方法，中国，ZL202210231728.X