罗富均研究员
研究简介
通过构建呼吸和重大神经疾病的转基因小鼠模型、结合各种分子和基因手段、膜片钳电生理记录、在体光纤记录、光遗传和行为学等交叉学科技术，系统解析大脑中枢控制呼吸以及咳嗽的分子、细胞、环路及其病理机制。另外，拟通过神经、行为层面操纵呼吸，以研究呼吸对应激和情感的调控。主要工作发表于Neuron, Nature Communications, EMBO J, PNAS, Cell Reports, J Neuroscience等期刊。
代表性成果
1. Luo F#*, Sclip A#, Merril S, Südhof TC. 2021 Neurexins regulate presynaptic GABAB receptors at central synapses. Nat. Commun.
2. Luo F*, Sclip A, M Jiang, Südhof TC*. 2020 Neurexins Cluster Ca2+ Channels within the Presynaptic Active Zone. EMBO J.
3. Luo F, Liu X, Südhof TC and Acuna C. 2017 Efficient Stimulus-Secretion Coupling at Retina Ribbon Synapses Requires RIM-BP Tethering of L-type Ca2+-Channels. PNAS 114: E8081-8090.
4. Luo F* and Südhof TC*. 2017 Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse. Neuron, 94: 826-839.
5. Maxeiner S#, Luo F#, Tan A, Schmitz F, Südhof TC. 2016 How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release. EMBO J.35(10):1098-114.