苗智超研究员
研究简介
从事单细胞组学和生物大分子结构模拟的计算生物学研究，聚焦呼吸疾病免疫原理、mRNA疫苗设计等。将人工智能、大数据等与生物医学研究深度结合，研发新的计算理论与算法来解决生物医学问题。单细胞组学方面，参与人类细胞图谱计划和单细胞表达图谱项目，主导研发多个领域内的核心算法，并曾作为欧洲研究基金单细胞组学方向的评委。生物大分子结构模拟方面，十多年来作为全球RNA三维结构预测比赛负责人主持该项目，制定了领域的评价规则。发表论文50余篇，第一或通讯作者论文20余篇，包括Nature Methods（2篇），Nature Neurosciences，Nature Communications，Nature Protocols，Genome Biology, NAR（5篇）等，引用超过6000次。
荣誉奖励
1.国家重大人才项目入选者（青年）
2.广州市黄埔区精英人才
代表性成果
1.(第一作者）Miao, Z., Moreno, P., Huang, N., Papatheodorou, I., Brazma, A. & Teichmann, S. A. 2020-05-18.《Putative cell type discovery from single-cell gene expression data.》.Nature Methods.（2020）17, 621–628
2.（共同一作）Büttner, M., Miao, Z., Wolf, F. A., Teichmann, S. A. & Theis, F. J.2018-12-20.《A test metric for assessing single-cell RNA-seq batch correction.》.Nature Methods.（2019）16, 43–49
3.（通讯作者）Hao, Z.-Z., Wei, J.-R., Xiao, D., Liu, R., Xu, N., Tang, L., Huang, M., Shen, Y., Xing, C., Huang, W., Liu, X., Xiang, M., Liu, Y., Miao, Z. &Liu,S.2022-05-30.《Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations.》.Nature Neuroscience.（2022）1–13
4.(共同一作）Natarajan, K. N.#^, Miao, Z.^, Jiang, M., Huang, X., Zhou, H., Xie, J., Wang, C., Qin, S., Zhao, Z., Wu, L., Yang, N., Li, B., Hou, Y., Liu, S. & Teichmann, S. A.#2018-12-20.《Comparative analysis of sequencing technologies for single-cell transcriptomics.》.Genome Biol. 20(1):70 (2019).
5.（通讯作者）Bu, F., Lin, X., Liao, W., Lu, Z., He, Y., Luo, Y., Peng, X., Li, M., Huang, Y., Chen, X., Xiao, B., Jiang, J., Deng, J., Huang, J., Lin, T., Miao, Z.#, Huang, L.#2023-10-19.《Ribocentre-switch: a database of riboswitches.》.Nucleic Acids Research.gkad891 (2023).
6.（通讯作者）Deng, J., Shi, Y., Peng, X., He, Y., Chen, X., Li, M., Lin, X., Liao, W., Huang, Y., Jiang, T., Lilley, D. M. J., Miao, Z. & Huang, L.2022-09-30.《Ribocentre: a database of ribozymes.》.Nucleic Acids Research.（2022）gkac840
7.（通讯作者）Magnus, M., Antczak, M., Zok, T., Wiedemann, J., Lukasiak, P., Cao, Y., Bujnicki, J. M., Westhof, E., Szachniuk, M. & Miao, Z.2020-01-24.《RNA-Puzzles toolkit: a computational resource of RNA 3D structure benchmark datasets, structure manipulation, and evaluation tools.》.Nucleic Acids Research.（2020）48, 576–588
8.（共同一作）Mamanova, L.#^, Miao, Z.^, Jinat, A., Ellis, P., Shirley, L. & Teichmann, S. A.#2021-05-14.《High-throughput full-length single-cell RNA-seq automation.》.Nature Protocols. 16, 2886–2915 (2021).
9.(共同一作）Natarajan, K. N., Miao, Z., Jiang, M., Huang, X., Zhou, H., Xie, J., Wang, C., Qin, S., Zhao, Z., Wu, L., Yang, N., Li, B., Hou, Y., Liu, S. & Teichmann, S. A.2019-04-09.《Comparative analysis of sequencing technologies for single-cell transcriptomics.》.Genome Biology.20(1):70 2022）
10.（通讯作者）Wei, J.-R., Hao, Z.-Z., Xu, C., Huang, M., Tang, L., Xu, N., Liu, R., Shen, Y., Teichmann, S. A., Miao, Z. & Liu, S. 2022-11-12.《Identification of visual cortex cell types and species differences using single-cell RNA sequencing.》.Nature Communications.13(1):1-21