景乃禾研究员
研究简介
长期从事哺乳动物早期胚胎发育的分子机制研究。通过建立小鼠早期胚胎空间转录组技术（Geo-seq），该课题组成功构建了小鼠早期胚胎的时空转录组图谱，揭示了原肠运动过程中三胚层发育分化的细胞谱系。景乃禾研究员在中枢神经系统发育及阿尔茨海默病（Alzheimer’s disease, AD）非人灵长类动物模型的建立方面取得了重要进展，其中“BMP信号在中枢神经系统发育中的作用机制研究”获得2014年度上海市自然科学一等奖。景乃禾研究员因在早期胚胎发育领域的突出贡献，荣获2019年度中国细胞生物学学会干细胞生物学分会“干细胞研究创新奖”，成果入选2019年度中国生命科学十大进展。景乃禾研究员在广州实验室的主要研究方向为：呼吸系统发育机制及衰老对呼吸系统疾病的影响。
荣誉奖励
1.2019年度中国生命科学十大进展
2.2014年上海市自然科学一等奖
3.国务院“政府特殊津贴”（1993-今）
1.2019年度中国生命科学十大进展
2.2014年上海市自然科学一等奖
3.国务院“政府特殊津贴”（1993-今）
代表性成果
1. Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C Marioni, Patrick P L Tam*, Naihe Jing*. Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nature Communications. 2023, 14(1): 5675.
2. Feng Yue*, Su Feng, Chunling Lu, Ting Zhang, Guoxian Tao, Jing Liu, Chunmei Yue*, Naihe Jing*. Synthetic amyloid-β oligomers drive early pathological progression of 2 Alzheimer’s Disease in nonhuman primates. iScience. 2021, 24(10): 103207.
3. Guangdun Peng*, Guizhong Cui, Jincan Ke, Naihe Jing*. Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genomics Hum Genet. 2020, 21: 163-181.
4. Guangdun Peng*, Shengbao Suo, Guizhong Cui，Fang Yu，Ran Wang，Jun Chen, Shirui Chen，Zhiwen Liu，Guoyu Chen，Yun Qian，Patrick. P.L. Tam, Jing-Dong J. Han*, Naihe Jing*. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019, 572(7770): 528–532.
5. Xianfa Yang, Boqiang Hu, Jiaoyang Liao, Yunbo Qiao, Yingying Chen, Yun Qian, Su Feng, Fang Yu, Yu Hou, He Xu, Guangdun Peng, Jinsong Li*, Fuchou Tang*, Naihe Jing*. Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Research. 2019, 29(11): 911-926.
6. Xianfa Yang, Boqiang Hu, Yu Hou, Yunbo Qiao*, Ran Wang, Yingying Chen, Yun Qian, Su Feng, Jun Chen, Chang Liu, Guangdun Peng, Fuchou Tang*, Naihe Jing*. Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic andextraembryonic lineages. Cell Research. 2018, 28(5): 593–596.
7. Jun Chen, Shengbao Suo, Patrick. P.L. Tam, Jing-Dong J. Han, Guangdun Peng*, Naihe Jing*. Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocols. 2017, 12(3): 566-580.
8. Guangdun Peng, Shengbao Suo, Jun Chen, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P. L. Tam, Jing-Dong Jackie Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-Gastrula Mouse Embryo. Developmental Cell. 2016, 36(6): 681-697.
9. Pingyu Liu, Xiaoyang Dou, Chang Liu, Lingbo Wang, Can Xing, Guangdun Peng, Jun Chen, Fang Yu,Yunbo Qiao, Lu Song, Yuxuan Wu, Chunmei Yue, Jinsong Li, Jing-Dong J. Han, Ke Tang & Naihe Jing*. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate. Nature Communications. 2015, 6: 6830.
10. Ge Bai, Nengyin Sheng, Zhihui Xie, Wei Bian, Yoshifumi Yokota, Robert Benezra, Ryoichiro Kageyama, Francois Guillemot, Naihe Jing*. Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Developmental Cell. 2007, 13(2): 283-297.