廖矿标研究员
研究简介
利用自动化、高通量、人工智能等现代化学技术，开发新型合成方法学，建立人工智能反应预测模型，聚焦PLPRO等呼吸系统疾病靶标开展新药研发。
1.合成方法学：围绕惰性化学键（碳氢键、碳碳键等）精准转化，定向开发方法学。
2.反应预测模型：利用自动化高通量技术，收集标准化的反应数据，建立人工智能反应预测模型，实现合成路径、反应条件或反应结果的精准预测，目前在研项目包括脱羧偶联、碳氢活化、多组分反应、不对称催化、光催化等类型的反应或反应体系。
3.呼吸系统疾病新药研发：开发新型化合物库合成以及活性筛选工具，研发抗冠状病毒的小分子药物。
荣誉奖励
1. 广东青年五四奖章
2. 广州市最美科技工作者
3. 黄埔区广州开发区最美科技工作者
4. 国家重大人才项目（青年）
5. 广州市优秀专家
6. 广州市黄埔区优秀人才
7. Reaxys PhD Prize Finalist
8. Osborne R. Quayle Student Achievement Award
代表性成果
1.Kuangbiao Liao, Solymar Negretti, Djamaladdin G. Musaev, John Bacsa & Huw M. L. Davies. 2016. Site-selective and stereoselective functionalization of unactivated C–H bonds. Nature. 533 (230–234).
2.Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G. Musaev & Huw M. L. Davies. 2017. Site-selective anstereoselective functionalization of non-activated tertiary C–H bonds. Nature. 551 (609–613).
3.Kuangbiao Liao,Yun-Fang Yang,Yingzi Li,Jacob N. Sanders,K. N. Houk,Djamaladdin G. Musaev &Huw M. L. Davies. 2018. Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds. Nature Chemistry. 10(1048–1055).
4.Huw M. L. Davies & Kuangbiao Liao. 2019. Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalization. Nature Reviews Chemistry. 3 (347–360).
5.Jia Qiu#, Jiancong Xie#, Shimin Su, Yadong Gao, Han Meng, Yuedong Yang* & Kuangbiao Liao*. 2022. Selective Functionalization of Hindered meta-C–H bond of o-Alkylaryl Ketones Promoted by Automation and Deep Learning. Chem. 8 (3275-3287).
6.Jia Qiu, Yougen Xu, Shimin Su, Yadong Gao, Peiyuan Yu, Zhixiong Ruan* & Kuangbiao Liao*. 2023. Auto Machine Learning Assisted Preparation of Carboxylic Acid by TEMPO-Catalyzed Primary Alcohol Oxidation. Chin. J. Chem. 41 (143-150).
7.Yougen Xu, Feixiao Ren, Lebin Su*, Zhaoping Xiong, Xinwei Zhu, Xinyuan Lin, Nan Qiao, Hao Tian, Changen Tian & Kuangbiao Liao*. 2023. HTE and machine learning-assisted development of iridium (I)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones. Org. Chem. Front. 10 (1153-1159).
8.Zhunzhun Yu, Yaxian Kong, Baiqing Li, Shimin Su, Jianhang Rao, Yadong Gao, Tianyong Tu, Hongming Chen* & Kuangbiao Liao*. 2023. HTE and AI-Assisted Development of DHP Catalyzed Decarboxylative Selenation. Chem. Comm. 59 (2935-2938).
9.Yougen Xu, Yadong Gao, Lebin Su*, Haiting Wu, Hao Tian, Majian Zeng, Chunqiu Xu, Xinwei Zhu & Kuangbiao Liao*. 2023. High-Throughput Experimentation and Machine Learning-Assisted Optimization of Iridium-Catalyzed Cross-Dimerization of Sulfoxonium Ylides. Angew. Chem. Int. Ed. 62, e202313638.
10. 一种由尿素衍生物制备1-萘胺类化合物的方法及其预测模型. 中国. ZL 2023 1 0307448.7. 2023年07月18日. 廖矿标，苏乐斌