陈凌研究员
研究简介
长期从事呼吸道病原、疫苗及抗体相关研究，主要包括腺病毒、流感病毒、新冠病毒等。拥有丰富的腺病毒载体疫苗研发经验积累，2000年以前在默克研发的腺病毒载体艾滋病疫苗是当时最具创新性的疫苗之一。新冠疫情发生后，全力开展疫苗研究并推动鼻喷疫苗研发，研发了广州第一个进入临床试验的新冠疫苗（腺病毒载体），获得8项新冠疫苗专利授权。课题组拥有多样完善的抗体研发平台，在流感、埃博拉、腺病毒、新冠抗体研究中积累的丰富的经验，近来开展鲨鱼纳米抗体及免疫组库研究，并已取得系列原始创新成果。此外，课题组在新型腺病毒、流感病毒载体研发，免疫代谢，黏膜免疫机制方面开展系列研究，推动基础研究与产业化结合发展。
荣誉奖励
1. 国家杰出青年科学基金获得者（外籍）
2. 国家重大人才项目入选者
3. 全国科技系统抗击新冠肺炎疫情先进个人
4. 南粤友谊奖
代表性成果
1.Wang Q, Yang C, Yin L, Sun J, Wang W, Li H, Zhang Z, Chen S, Liu B, Liu Z, Shi L, Liu X, Guan S, Wang C, Qu L, Feng Y, Niu X, Feng L, Zhao J, Li P, Chen L, Zhong N. Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants. Signal Transduct Target Ther. 2023 Apr 17;8(1):167. （IF=39.3 ）
2.Yan Q, Zhang Y, Hou R, Pan W, Liang H, Gao X, Deng W, Huang X, Qu L, Tang C, He P, Liu B, Wang Q, Zhao X, Lin Z, Chen Z, Li P, Han J, Xiong X, Zhao J, Li S, Niu X, Chen L. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents. Emerg Microbes Infect. 2023 Dec 4:2290841. （IF=13.2 ）
3.He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nature Microbiology. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. （IF=28.3）
4.Li P, Wang Q, He Y, Yang C, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L, Chen L. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerging Microbes & Infection. 2022 Oct 14:1-51. doi: 10.1080/22221751.2022.2136538. （IF=13.2 ）
5.Feng B, Chen Z, Sun J, Xu T, Wang Q, Yi H, Niu X, Zhu J, Fan M, Hou R, Shao Y, Huang S, Li C, Hu P, Zheng P, He P, Luo J, Yan Q, Xiong X, Liu J, Zhao J,Chen L. A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape. Small Methods. 2022 May 18:e2200387. （IF=12.4）
6.Yan Q, He P, Huang X, Luo K, Zhang Y, Yi H, Wang Q, Li F, Hou R, Fan X, Li P, Liu X, Liang H, Deng Y, Chen Z, Chen Y, Mo X, Feng L, Xiong X, Li S, Han J, Qu L, Niu X, Chen L. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):1097-1111.（IF=13.2 ）
7.Feng L, Wang Q, Shan C, Yang C, Feng Y, Wu J, Liu X, Zhou Y, Jiang R, Hu P, Liu X, Zhang F, Li P, Niu X, Liu Y, Zheng X, Luo J, Sun J, Gu Y, Liu B, Xu Y, Li C, Pan W, Zhao J, Ke C, Chen X, Xu T, Zhong N, Guan S, Yuan Z, Chen L. An adenovirus vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nat Commun. 2020, 11: 4207. （IF=16.6 ）
8.Sun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, Peng P, Liu X, Chen Z, Huang H, Zhang F, Luo W, Niu X, Hu P, Wang L, Peng H, Huang Z, Feng L, Li F, Zhong N, Chen L. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerg Microbes Infect 2020; 9(1): 940-8.（IF=13.2 ）
9.Yang Q, Feng F, Li P, Pan E, Wu C, He Y, Zhang F, Zhao J, Li R, Feng L, Hu F, Li L, Zou H, Cai W, Lehner T, Sun C, Chen L. Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. Adv Sci (Weinh). 2019 May 7;6(13):1900319. （IF=15.1 ）
10.Pan W, Dong Z, Li F, Meng W, Feng L, Niu X, Li C, Luo Q, Li Z, Sun C, Chen L. Visualizing influenza virus infection in living mice. Nat Commun. 2013;4:2369.（IF=16.6 ）