李佳研究员
研究简介
长期从事研究计算表观遗传学，主要利用生物信息学方法通过系统深入挖掘多维度表观组学大数据（单细胞表观组、DNA/组蛋白修饰组和染色体三维结构等），探索重大疾病的发生机制，并以此为基础开发新型基于表观分子标记的液体活检技术，用以早期检测重大呼吸疾病的发生、监测病情发展和评估治疗效果。以第一/通讯（含共同）作者发表在Nat Cell Biology, Sci Adv，Nat Aging，Nat Commun x 3, JCI, NAR等10余篇（其中IF>10的12篇），被引用1000余次，h-index 20，现主持国自然面上等多项国家级项目。
荣誉奖励
1.广东省重大人才项目（青年）
代表性成果
1.Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukemia cell growth ;Nature Cell Biology.2024；IF：21.3, I区（倒数第二共通讯）
2.Single-cell transcriptomics reveals e-cigarette vapor-induced airway epithelial remodeling and injury ；Respiratory Research.2024.（共一第二）
3.Hong T, Li J, et al. TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nature Aging. 2023 Oct 26:1-4.（共一/共通讯）
4.Yang P, Luo Q, Wang X, Fang Q, Fu Z, Li J, et al. Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases. American Journal of Respiratory and Critical Care Medicine. 2023 Jan 15;207(2):160-72.（共一）
5.Li J, Hong T, et al. Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms. Clinical epigenetics. 2022 Dec;14(1):1-4. （第一作者）
6.Zhao S, Li J, Zhang H, et al. Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas. Nature communications. 2022 Nov 5;13(1):6689. （共一）
7.Fang S, Cui D, …, Li J, Huang Y. Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells. Stem Cells. 2022 Mar 1;40(3):260-72. （倒数第二共同通讯）
8.Chen YS, Li J, et al. Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes. 2021 Jan 1;13(1):1972756. （共一）
9.Yin Y, Li J, Li J, et al. LiBis: an ultrasensitive alignment augmentation for low-input bisulfite sequencing. Briefings in bioinformatics. 2021 Jul;22(4):bbaa332. （共一）
10.Li J, Zhao S, Lee M, et al. Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science advances. 2020 Oct 16;6(42):eabb5427. （第一作者）
荣誉奖励
1.广东省重大人才项目（青年）
代表性成果
1.Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukemia cell growth ;Nature Cell Biology.2024；IF：21.3, I区（倒数第二共通讯）
2.Single-cell transcriptomics reveals e-cigarette vapor-induced airway epithelial remodeling and injury ；Respiratory Research.2024.（共一第二）
3.Hong T, Li J, et al. TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nature Aging. 2023 Oct 26:1-4.（共一/共通讯）
4.Yang P, Luo Q, Wang X, Fang Q, Fu Z, Li J, et al. Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases. American Journal of Respiratory and Critical Care Medicine. 2023 Jan 15;207(2):160-72.（共一）
5.Li J, Hong T, et al. Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms. Clinical epigenetics. 2022 Dec;14(1):1-4. （第一作者）
6.Zhao S, Li J, Zhang H, et al. Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas. Nature communications. 2022 Nov 5;13(1):6689. （共一）
7.Fang S, Cui D, …, Li J, Huang Y. Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells. Stem Cells. 2022 Mar 1;40(3):260-72. （倒数第二共同通讯）
8.Chen YS, Li J, et al. Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes. 2021 Jan 1;13(1):1972756. （共一）
9.Yin Y, Li J, Li J, et al. LiBis: an ultrasensitive alignment augmentation for low-input bisulfite sequencing. Briefings in bioinformatics. 2021 Jul;22(4):bbaa332. （共一）
10.Li J, Zhao S, Lee M, et al. Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science advances. 2020 Oct 16;6(42):eabb5427. （第一作者）